Duration

4 Years

Funding

6.3 Mio

11 Partners

7 Countries

cmRNAbone - A NOVEL GENE THERAPY FOR BONE REGENERATION

Due to demographic change, bone degenerating diseases like osteoporosis have a growing societal and financial impact on industrialised nations. It is estimated that worldwide one in three women and one in five men over the age of 50 will experience osteoporotic bone fracture. Moreover, although most fractures will heal without complications under appropriate treatment, there are additional cases of impaired bone regeneration, e.g. large trauma with infections after car accidents.

With bone being the most transplanted tissue after blood, the need for graft materials is enormous. In search of optimised regeneration solutions, the EU-funded cmRNAbone project has set out to develop a novel gene therapy to improve the lives of people with large traumatic injuries or bone degenerating diseases such as osteoporosis.

“One of our top priorities is the timely translation of the project results to the clinic. In order to reach our ambitious project goals and achieve more effective patient care worldwide, we have brought together balanced team combining the innovation potential of SMEs with the market experience of research institutes and the large international track records of our participating universities and university hospitals. ”

Prof. David Eglin, Coordinator
AO Research Institute Davos, Switzerland

Core Activities

  • Creation of an innovative bone regenerative therapeutic approach for trauma and osteoporotic patients
  • Development of specific chemically modified RNAs and vector systems
  • Design and fabrication of transcript activated ink matrices for 3D Printing
  • Co-development of injectable therapeutic solutions and purpose-built 3D printer for
  • in-situ production of patient specific biofunctional implants
  • Preparation of the regenerative solution for clinical trial readiness under expert regulatory guidance